Acetazolamide and RP- Case Study

en, J. C.
Articles by Bird, A. C.
Investigative Ophthalmology & Visual Science, Vol 31, 1914-1918, Copyright © 1990 by Association for Research in Vision and Ophthalmology
ARTICLES AND REPORTS
Long-term effect of acetazolamide in a patient with retinitis pigmentosa
JC Chen, FW Fitzke and AC Bird Department of Clinical Ophthalmology, University of London, England.
The authors studied the therapeutic effect of acetazolamide on a patient with autosomal dominant retinitis pigmentosa complicated by retinal edema. In addition to reduction of macular edema and some improvement of central vision, they found an unexpected progressive increase in extrafoveal retinal sensitivity with prolonged medication. It is proposed that the therapeutic effect is mediated by alteration of retinal pigment epithelial function and that disturbed polarity is restored to a more normal state.
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